ISLR2

Across TCGA patient cohorts, ISLR2 protein abundance is significantly associated with the RNA expression of many other genes, with 956 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ISLR2-associated genes across cancer lineages are PRODH, FBXO7, and SUN2. Each is linked with ISLR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISLR2-to-partner and partner-to-ISLR2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ISLR2 versus PRODH in GBM, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISLR2→partner) and Y-score (partner→ISLR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRODH →	+0.907	+0.497	.005	.001	3	1
GBM	FBXO7 →	+0.261	+0.363	.007	.002	3	1
GBM	SUN2 →	+0.381	+0.466	.008	.004	3	1
GBM	RASL10A →	+0.657	+0.515	.003	<.001	3	1
GBM	NEFH →	+1.068	+0.612	<.001	<.001	3	1
GBM	SYNGR1 →	+0.619	+0.319	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 956 associations by consensus.

ISLR2 vs PRODH — GBM

Explore this scatter interactively →