ISLR2

Across TCGA patient cohorts, ISLR2 mutation is significantly associated with the RNA expression of many other genes, with 6,503 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ISLR2-associated genes across cancer lineages are RAD51AP1, NEK2, and DUT. Each is linked with ISLR2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ISLR2-to-partner and partner-to-ISLR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51AP1 grouped by ISLR2-low versus ISLR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISLR2→partner) and Y-score (partner→ISLR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51AP1 →	+0.550	+3.129	.002	<.001	3	4
UCEC	NEK2 →	+0.491	+2.264	.006	.001	3	4
UCEC	DUT →	+0.508	+2.291	<.001	<.001	3	4
COAD	COQ3 →	+0.565	+2.335	<.001	<.001	3	4
UCEC	CENPE →	+0.596	+2.055	<.001	<.001	3	4
COAD	IER3IP1 →	+0.585	+2.820	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,503 associations by consensus.

RAD51AP1 by ISLR2 expression — UCEC

Explore this box plot interactively →