ISLR2

Across TCGA patient cohorts, ISLR2 mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ISLR2-associated genes across cancer lineages are eEF2, PDCD4, and Caspase-7-cleavedD198. Each is linked with ISLR2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ISLR2-to-partner and partner-to-ISLR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ISLR2-low versus ISLR2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISLR2→partner) and Y-score (partner→ISLR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eEF2 →	+0.394	+1.915	<.001	.009	3	4
UCEC	PDCD4 →	-0.481	-1.836	.001	.001	3	4
COAD	Caspase-7-cleavedD198 →	+1.378	+3.095	<.001	<.001	3	4
COAD	c-Kit →	-0.677	-2.115	.001	.017	3	4
COAD	eIF4E →	+0.191	+1.932	.003	.009	3	3
UCEC	ERK2 →	+0.201	+2.321	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

eEF2 by ISLR2 expression — COAD

Explore this box plot interactively →