ISLR2

Across TCGA cell cohorts, ISLR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,130 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ISLR2-associated GO terms across cancer lineages are Regulation of RNA splicing, Regulation of G1/S transition of mitotic cell cycle, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with ISLR2 in more than 9 cancer types. Because this analysis shows association rather than direction, both ISLR2-to-partner and partner-to-ISLR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of RNA splicing grouped by ISLR2-low versus ISLR2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ISLR2→partner) and Y-score (partner→ISLR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of RNA splicing →	+0.055	+1.959	.002	.005	3	10
LARGE_INTESTINE	Regulation of G1/S transition of mitotic cell cycle →	+0.055	+0.096	<.001	<.001	3	10
LUNG_SCLC	Negative regulation of syncytium formation by plasma membrane fusion →	+0.128	+2.742	<.001	<.001	3	9
LARGE_INTESTINE	Regulation of organelle assembly →	+0.044	+0.114	<.001	<.001	3	9
LIVER	Regulation of ubiquitin-dependent protein catabolic process →	+0.063	+0.319	<.001	.007	3	9
LUNG_SCLC	Negative regulation of myoblast fusion →	+0.128	+2.509	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,130 associations by consensus.

Regulation of RNA splicing by ISLR2 expression — LUNG_SCLC

Explore this box plot interactively →