ISLR2

Across TCGA cell cohorts, ISLR2 mutation is significantly associated with the RNA expression of many other genes, with 515 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ISLR2-associated genes across cancer lineages are SAMM50, SH3GL2, and MAPK8. Each is linked with ISLR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISLR2-to-partner and partner-to-ISLR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAMM50 grouped by ISLR2-low versus ISLR2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISLR2→partner) and Y-score (partner→ISLR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SAMM50 →	+0.521	+3.082	.001	.007	3	2
LARGE_INTESTINE	SH3GL2 →	+0.911	+2.667	.004	.007	3	2
LARGE_INTESTINE	MAPK8 →	+0.583	+3.169	.007	.009	3	2
LARGE_INTESTINE	ZNF330 →	+0.523	+3.743	<.001	<.001	3	2
LARGE_INTESTINE	NEIL3 →	+0.684	+3.389	.001	.001	3	2
LARGE_INTESTINE	TBCCD1 →	+0.501	+3.169	.006	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 515 associations by consensus.

SAMM50 by ISLR2 expression — LARGE_INTESTINE

Explore this box plot interactively →