ISLR

Across TCGA pan-cancer cohorts, ISLR mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ISLR data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ISLR mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ISLR expression acts as an unfavorable survival marker.

LSCC, UCEC, and CCRCC are the cancer types where ISLR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	III,IV	0.244	0.836	.001	34	view →
UCEC	OS	Tertile	II,III,IV	0.568	1.000	.016	12	view →
CCRCC	DFS	Quartile	III,IV	0.140	0.887	.038	6	view →
PDAC	DFS	Median	II,III,IV	0.659	0.882	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ISLR–LSCC (OS)

Open the LSCC breakdown →