ISL1

Across TCGA cell cohorts, ISL1 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ISL1-associated genes across cancer lineages are OR8B2, OR2AT4, and LGALS13. Each is linked with ISL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISL1-to-partner and partner-to-ISL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B2 grouped by ISL1-low versus ISL1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISL1→partner) and Y-score (partner→ISL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR8B2 →	+0.047	+4.969	<.001	.003	3	2
LARGE_INTESTINE	OR2AT4 →	+0.020	+4.196	<.001	.002	3	2
BLOOD_Leukemia	LGALS13 →	+0.663	+4.969	<.001	.003	3	1
BLOOD_Leukemia	OPN5 →	+0.058	+4.409	<.001	.005	3	1
BLOOD_Leukemia	AIPL1 →	+0.052	+4.152	<.001	.009	3	1
BLOOD_Leukemia	C1orf158 →	+0.351	+4.276	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

OR8B2 by ISL1 expression — BLOOD_Leukemia

Explore this box plot interactively →