ISG20L2

Across TCGA patient cohorts, ISG20L2 protein abundance is significantly associated with the RNA expression of many other genes, with 16,597 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ISG20L2-associated genes across cancer lineages are UBE2Q1, CCT3, and TGFBR2. Each is linked with ISG20L2 in more than 6 cancer types. Because this analysis shows association rather than direction, both ISG20L2-to-partner and partner-to-ISG20L2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ISG20L2 versus UBE2Q1 in LSCC, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISG20L2→partner) and Y-score (partner→ISG20L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UBE2Q1 →	+0.514	+0.294	<.001	<.001	3	6
UCEC	CCT3 →	+0.816	+0.313	.001	<.001	2	7
LSCC	TGFBR2 →	-0.746	-0.307	<.001	<.001	3	6
BRCA	ZCCHC24 →	-0.905	-0.272	<.001	<.001	3	6
UCEC	CKS1B →	+0.994	+0.249	.001	<.001	3	6
BRCA	FCER1A →	-1.763	-0.406	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,597 associations by consensus.

ISG20L2 vs UBE2Q1 — LSCC

Explore this scatter interactively →