ISG20L2

Across TCGA patient cohorts, ISG20L2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ISG20L2-associated genes across cancer lineages are ERK2, Fibronectin, and JNK2. Each is linked with ISG20L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISG20L2-to-partner and partner-to-ISG20L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ISG20L2-low versus ISG20L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISG20L2→partner) and Y-score (partner→ISG20L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.190	+3.169	.034	.019	3	1
UCEC	Fibronectin →	-0.315	-2.312	.040	.034	3	1
UCEC	JNK2 →	+0.250	+2.817	.006	.036	3	1
UCEC	Myosin-IIa →	+0.181	+2.592	.036	.006	3	1
UCEC	PDK1_pS241 →	+0.262	+3.459	<.001	.005	3	1
UCEC	PDK1 →	+0.114	+3.013	.023	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ERK2 by ISG20L2 expression — UCEC

Explore this box plot interactively →