ISG20L2

Across TCGA cell cohorts, ISG20L2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,019 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ISG20L2-associated GO terms across cancer lineages are mRNA 3'-end processing, rRNA metabolic process, and RNA 3'-end processing. Each is linked with ISG20L2 in more than 14 cancer types. Because this analysis shows association rather than direction, both ISG20L2-to-partner and partner-to-ISG20L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA 3'-end processing grouped by ISG20L2-low versus ISG20L2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ISG20L2→partner) and Y-score (partner→ISG20L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	mRNA 3'-end processing →	+0.099	+0.796	<.001	.001	3	15
PANCREAS	rRNA metabolic process →	+0.108	+0.790	<.001	<.001	3	14
BONE	RNA 3'-end processing →	+0.099	+0.803	<.001	<.001	3	14
SOFT_TISSUE	Host-mediated activation of viral transcription →	+0.110	+0.749	<.001	.005	3	14
BONE	Nucleic acid transport →	+0.123	+0.699	.002	.004	2	15
BONE	RNA transport →	+0.123	+0.699	.002	.004	2	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,019 associations by consensus.

mRNA 3'-end processing by ISG20L2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →