ISG20L2

Across TCGA cell cohorts, ISG20L2 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ISG20L2-associated genes across cancer lineages are PROP1, NCAN, and HTR1B. Each is linked with ISG20L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISG20L2-to-partner and partner-to-ISG20L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROP1 grouped by ISG20L2-low versus ISG20L2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISG20L2→partner) and Y-score (partner→ISG20L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PROP1 →	+0.029	+4.874	<.001	.002	3	1
LARGE_INTESTINE	NCAN →	+0.117	+3.629	.004	.003	3	1
LARGE_INTESTINE	HTR1B →	+0.049	+2.766	<.001	.005	3	1
LARGE_INTESTINE	TBR1 →	+0.047	+3.555	<.001	.003	3	1
LARGE_INTESTINE	SLCO1C1 →	+0.495	+3.035	<.001	.003	3	1
LARGE_INTESTINE	CPLX4 →	+0.031	+3.222	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

PROP1 by ISG20L2 expression — BLOOD_Leukemia

Explore this box plot interactively →