ISG20

Across TCGA patient cohorts, ISG20 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,988 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ISG20-associated proteins across cancer lineages are RASAL3, CORO1A, and CRLF3. Each is linked with ISG20 in more than 8 cancer types. Because this analysis shows association rather than direction, both ISG20-to-partner and partner-to-ISG20 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ISG20 versus RASAL3 in GBM, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ISG20→partner) and Y-score (partner→ISG20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RASAL3 →	+0.496	+0.673	<.001	<.001	3	9
LSCC	CORO1A →	+0.652	+0.705	<.001	<.001	3	9
OV	CRLF3 →	+0.364	+0.776	.002	<.001	3	9
BRCA	OAS2 →	+0.828	+0.875	<.001	<.001	3	8
BRCA	PARP14 →	+0.439	+0.853	<.001	<.001	3	8
LSCC	PTPRC →	+0.693	+0.921	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,988 associations by consensus.

ISG20 vs RASAL3 — GBM

Explore this scatter interactively →