ISG20

Across TCGA patient cohorts, ISG20 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ISG20-associated genes across cancer lineages are eIF4G, Tuberin, and Cyclin-E2. Each is linked with ISG20 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISG20-to-partner and partner-to-ISG20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by ISG20-low versus ISG20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISG20→partner) and Y-score (partner→ISG20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.400	+3.000	.025	.037	3	1
UCEC	Tuberin →	+0.335	+2.817	.031	.036	3	1
UCEC	Cyclin-E2 →	+0.225	+2.817	.021	.036	2	1
UCEC	Rictor_pT1135 →	-0.128	-3.000	.030	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

eIF4G by ISG20 expression — UCEC

Explore this box plot interactively →