ISG20

Across TCGA cell cohorts, ISG20 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,256 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ISG20-associated GO terms across cancer lineages are Negative regulation of viral genome replication, Apoptotic signaling pathway, and Negative regulation of viral process. Each is linked with ISG20 in more than 11 cancer types. Because this analysis shows association rather than direction, both ISG20-to-partner and partner-to-ISG20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of viral genome replication grouped by ISG20-low versus ISG20-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ISG20→partner) and Y-score (partner→ISG20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Negative regulation of viral genome replication →	+0.183	+1.984	.001	.004	3	12
PANCREAS	Apoptotic signaling pathway →	+0.065	+1.960	<.001	<.001	3	11
KIDNEY	Negative regulation of viral process →	+0.182	+2.666	.002	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of response to type II interferon →	+0.139	+1.587	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Negative regulation of type II interferon-mediated signaling pathway →	+0.139	+1.587	<.001	<.001	3	10
KIDNEY	Regulation of viral life cycle →	+0.106	+2.140	.002	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,256 associations by consensus.

Negative regulation of viral genome replication by ISG20 expression — KIDNEY

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