Across TCGA patient cohorts, ISG15 RNA expression is significantly associated with the RNA expression of many other genes, with 14,247 significant associations in total. THYM shows the largest number of these associations.

The most reproducible ISG15-associated genes across cancer lineages are IFI35, IFI6, and IFI44. Each is linked with ISG15 in more than 33 cancer types. Because this analysis shows association rather than direction, both ISG15-to-partner and partner-to-ISG15 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISG15→partner) and Y-score (partner→ISG15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	IFI35 →	+1.745	+2.019	<.001	<.001	3	34
MESO	IFI6 →	+3.041	+2.833	<.001	<.001	3	34
BLCA	IFI44 →	+2.209	+1.786	<.001	<.001	3	34
UCS	MX1 →	+2.602	+2.457	<.001	<.001	3	34
UVM	IFITM1 →	+2.753	+2.505	<.001	<.001	3	34
UVM	PSMB9 →	+2.592	+2.211	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,247 associations by consensus.

Exploration

ISG15 survival (RNA) · tumor vs normal (RNA) · all ISG15 data types