ISG15

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, ISG15 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,502 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible ISG15-associated proteins across cancer lineages are IFIT3, CMPK2, and DDX58. Each is linked with ISG15 in more than 9 cancer types. Because this analysis shows association rather than direction, both ISG15-to-partner and partner-to-ISG15 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ISG15→partner) and Y-score (partner→ISG15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCIFIT3 →+1.224+2.021<.001<.001310
LSCCCMPK2 →+0.692+1.680<.001<.00139
OVDDX58 →+0.818+1.837<.001<.00139
OVDTX3L →+0.557+1.603<.001<.00139
OVDTX3L_S539 →+0.639+1.409<.001<.00139
OVEIF2AK2 →+0.526+1.907<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 10,502 associations by consensus.

Exploration