Across TCGA patient cohorts, ISG15 protein abundance is significantly associated with the RNA expression of many other genes, with 7,102 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible ISG15-associated genes across cancer lineages are DDX58, OAS3, and OAS2. Each is linked with ISG15 in more than 9 cancer types. Because this analysis shows association rather than direction, both ISG15-to-partner and partner-to-ISG15 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISG15→partner) and Y-score (partner→ISG15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DDX58 →	+1.191	+1.138	<.001	<.001	3	10
LSCC	OAS3 →	+1.371	+0.949	<.001	<.001	3	10
LSCC	OAS2 →	+1.475	+1.025	<.001	<.001	3	10
HNSC	IFIH1 →	+1.158	+1.038	<.001	<.001	3	10
BRCA	STAT1 →	+1.026	+0.884	<.001	<.001	3	10
HNSC	IFIT3 →	+1.768	+1.071	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,102 associations by consensus.

Exploration

ISG15 survival (RNA) · tumor vs normal (RNA) · all ISG15 data types