ISG15

RNA expression — cross-omics
Cross-omicsRNA → FUNCTION-RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, ISG15 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,223 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible ISG15-associated GO terms across cancer lineages are Regulation of viral life cycle, Negative regulation of viral genome replication, and Negative regulation of viral process. Each is linked with ISG15 in more than 17 cancer types. Because this analysis shows association rather than direction, both ISG15-to-partner and partner-to-ISG15 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ISG15→partner) and Y-score (partner→ISG15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner GO termX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
KIDNEYRegulation of viral life cycle →+0.137+3.617<.001<.001318
URINARY_TRACTNegative regulation of viral genome replication →+0.218+3.406<.001<.001318
KIDNEYNegative regulation of viral process →+0.187+3.005.001<.001318
UPPER_AERODIGESTIVE_TRACTRegulation of viral process →+0.109+2.308<.001<.001318
UPPER_AERODIGESTIVE_TRACTCytoplasmic pattern recognition receptor signaling pathway →+0.090+2.584<.001<.001317
BREASTNegative regulation of response to biotic stimulus →+0.104+2.954<.001<.001317
Each partner links to its Q-omics profile. Showing the 6 strongest of 4,223 associations by consensus.

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