ISCU

Across TCGA pan-cancer cohorts, ISCU Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ISCU data layer compared with 29 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ISCU Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ISCU expression acts as an unfavorable survival marker.

KIRC, LUAD, and COAD are the cancer types where ISCU Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.123	0.805	<.001	42	view →
LUAD	OS	Median	All	0.245	0.835	<.001	21	view →
COAD	OS	Median	All	0.111	0.871	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ISCU–KIRC (OS)

Open the KIRC breakdown →