ISCU

Across TCGA pan-cancer cohorts, ISCU mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ISCU data layer compared with 29 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ISCU mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ISCU expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, LSCC, and UCEC are the cancer types where ISCU mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.973	0.700	.001	40	view →
LSCC	OS	Median	All	1.000	0.940	.017	9	view →
UCEC	DFS	Median	All	0.935	1.000	.020	8	view →
PDAC	OS	Median	III,IV	1.000	0.537	.008	6	view →
CCRCC	DFS	Quartile	II,III,IV	0.354	0.753	.009	5	view →
HNSC	DFS	Median	III,IV	0.526	0.717	.029	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ISCU–LUAD (DFS)

Open the LUAD breakdown →