ISCA2

Across TCGA pan-cancer cohorts, ISCA2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ISCA2 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ISCA2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ISCA2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and OV are the cancer types where ISCA2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	0.951	0.547	.001	27	view →
CCRCC	OS	Quartile	II,III,IV	0.985	0.104	.024	10	view →
OV	DFS	Median	All	0.862	1.000	.037	4	view →
UCEC	DFS	Median	II,III,IV	0.490	0.923	.005	4	view →
PDAC	DFS	Quartile	All	0.535	0.288	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ISCA2–LSCC (OS)

Open the LSCC breakdown →