ISCA2

Across TCGA patient cohorts, ISCA2 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,450 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ISCA2-associated proteins across cancer lineages are SETD3, MTHFD1, and AHSA1. Each is linked with ISCA2 in more than 8 cancer types. Because this analysis shows association rather than direction, both ISCA2-to-partner and partner-to-ISCA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ISCA2 versus SETD3 in CCRCC, with a Pearson correlation of 0.51.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ISCA2→partner) and Y-score (partner→ISCA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SETD3 →	+0.255	+0.329	<.001	<.001	3	9
COAD	MTHFD1 →	+0.359	+0.515	<.001	<.001	3	8
OV	AHSA1 →	+0.385	+0.613	<.001	<.001	3	8
OV	YLPM1 →	+0.334	+0.744	<.001	<.001	3	7
OV	UBR7 →	+0.399	+0.491	.002	.005	2	8
LSCC	PPP4R3A →	+0.303	+0.481	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,450 associations by consensus.

ISCA2 vs SETD3 — CCRCC

Explore this scatter interactively →