ISCA2

Across TCGA patient cohorts, ISCA2 protein abundance is significantly associated with the RNA expression of many other genes, with 9,085 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ISCA2-associated genes across cancer lineages are ALDH6A1, ZC2HC1C, and KIAA1841. Each is linked with ISCA2 in more than 5 cancer types. Because this analysis shows association rather than direction, both ISCA2-to-partner and partner-to-ISCA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ISCA2 versus ALDH6A1 in CCRCC, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISCA2→partner) and Y-score (partner→ISCA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ALDH6A1 →	+0.929	+0.313	<.001	<.001	3	6
OV	ZC2HC1C →	+0.565	+0.495	<.001	.001	3	5
OV	KIAA1841 →	-0.559	-0.569	.005	<.001	3	5
CCRCC	ARF4 →	-0.400	-0.292	.003	.001	3	5
BRCA	UTP11 →	-0.427	-0.419	<.001	<.001	3	5
BRCA	MSANTD3 →	-0.595	-0.458	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,085 associations by consensus.

ISCA2 vs ALDH6A1 — CCRCC

Explore this scatter interactively →