ISCA2

Across TCGA cell cohorts, ISCA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,194 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ISCA2-associated GO terms across cancer lineages are Oxidative RNA demethylation, Metallo-sulfur cluster assembly, and Iron-sulfur cluster assembly. Each is linked with ISCA2 in more than 9 cancer types. Because this analysis shows association rather than direction, both ISCA2-to-partner and partner-to-ISCA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Oxidative RNA demethylation grouped by ISCA2-low versus ISCA2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ISCA2→partner) and Y-score (partner→ISCA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Oxidative RNA demethylation →	+0.094	+0.554	.004	.001	3	10
STOMACH	Metallo-sulfur cluster assembly →	+0.089	+0.649	.002	.005	3	10
STOMACH	Iron-sulfur cluster assembly →	+0.089	+0.649	.002	.005	3	10
BLOOD_Myeloma	Protein catabolic process at synapse →	+0.159	+1.011	.002	.005	3	9
BLOOD_Myeloma	Protein catabolic process at postsynapse →	+0.159	+1.011	.002	.005	3	9
SKIN	Deoxyribose phosphate biosynthetic process →	+0.083	+0.475	.002	.004	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,194 associations by consensus.

Oxidative RNA demethylation by ISCA2 expression — LUNG_SCLC

Explore this box plot interactively →