ISCA1P4

Across TCGA patient cohorts, ISCA1P4 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,006 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible ISCA1P4-associated GO terms across cancer lineages are Regulation of translation initiation in response to endoplasmic reticulum stress, Protein import into peroxisome matrix, receptor recycling, and tRNA methylation. Each is linked with ISCA1P4 in more than 15 cancer types. Because this analysis shows association rather than direction, both ISCA1P4-to-partner and partner-to-ISCA1P4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translation initiation in response to endoplasmic reticulum stress grouped by ISCA1P4-low versus ISCA1P4-high in UVM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ISCA1P4→partner) and Y-score (partner→ISCA1P4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	Regulation of translation initiation in response to endoplasmic reticulum stress →	+0.069	+0.957	<.001	<.001	3	16
ACC	Protein import into peroxisome matrix, receptor recycling →	+0.043	+0.793	<.001	<.001	2	16
UVM	tRNA methylation →	+0.039	+0.743	<.001	<.001	3	15
STAD	DNA integrity checkpoint signaling →	+0.039	+0.373	.001	<.001	3	15
UVM	Protein targeting to peroxisome →	+0.058	+0.812	<.001	<.001	3	15
STAD	Cell cycle checkpoint signaling →	+0.042	+0.419	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,006 associations by consensus.

Regulation of translation initiation in response to endoplasmic reticulum stress by ISCA1P4 expression — UVM

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