IRX6

Across TCGA patient cohorts, IRX6 mutation is significantly associated with the RNA expression of many other genes, with 1,351 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRX6-associated genes across cancer lineages are CTU2, NCAPH2, and ETDB. Each is linked with IRX6 in more than 2 cancer types. Because this analysis shows association rather than direction, both IRX6-to-partner and partner-to-IRX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTU2 grouped by IRX6-low versus IRX6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX6→partner) and Y-score (partner→IRX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CTU2 →	+0.615	+3.483	<.001	.002	3	3
UCEC	NCAPH2 →	+0.597	+3.491	<.001	.002	3	3
HNSC	ETDB →	+0.037	+4.912	.008	.005	3	3
UCEC	ZNHIT3 →	+0.453	+2.343	.003	.003	3	3
UCEC	EEF2KMT →	+0.442	+2.343	.004	.003	3	3
STAD	PKMYT1 →	+0.825	+2.601	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,351 associations by consensus.

CTU2 by IRX6 expression — UCEC

Explore this box plot interactively →