IRX6

Across TCGA patient cohorts, IRX6 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. COAD shows the largest number of these associations.

The most reproducible IRX6-associated genes across cancer lineages are ATM, Rictor_pT1135, and Smad1. Each is linked with IRX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRX6-to-partner and partner-to-IRX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by IRX6-low versus IRX6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX6→partner) and Y-score (partner→IRX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.629	-2.700	.002	.006	3	2
STAD	Rictor_pT1135 →	-0.188	-2.984	.004	.034	3	1
STAD	Smad1 →	+0.152	+3.459	.014	.004	3	1
STAD	TIGAR →	+0.454	+3.169	.010	.018	3	1
STAD	Tuberin_pT1462 →	-0.197	-3.169	.019	.018	3	1
STAD	Chk2_pT68 →	-0.131	-2.459	.006	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ATM by IRX6 expression — UCEC

Explore this box plot interactively →