IRX6

Across TCGA cell cohorts, IRX6 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,998 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible IRX6-associated GO terms across cancer lineages are Regulation of RNA splicing, Cytoplasmic translation, and Cellular respiration. Each is linked with IRX6 in more than 7 cancer types. Because this analysis shows association rather than direction, both IRX6-to-partner and partner-to-IRX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of RNA splicing grouped by IRX6-low versus IRX6-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX6→partner) and Y-score (partner→IRX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of RNA splicing →	+0.063	+0.260	.001	.002	3	8
OESOPHAGUS	Cytoplasmic translation →	+0.099	+0.354	.002	.001	3	7
OESOPHAGUS	Cellular respiration →	+0.079	+0.329	.009	.005	3	6
OESOPHAGUS	Regulation of proteasomal protein catabolic process →	+0.059	+0.261	.002	.001	3	6
OESOPHAGUS	RNA export from nucleus →	+0.109	+0.306	.002	.004	3	6
SOFT_TISSUE	Negative regulation of mRNA metabolic process →	+0.082	+1.011	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,998 associations by consensus.

Regulation of RNA splicing by IRX6 expression — OESOPHAGUS

Explore this box plot interactively →