IRX6

Across TCGA cell cohorts, IRX6 mutation is significantly associated with the RNA expression of many other genes, with 276 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IRX6-associated genes across cancer lineages are KRTAP20-2, RBMY1A1, and MTRNR2L5. Each is linked with IRX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRX6-to-partner and partner-to-IRX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP20-2 grouped by IRX6-low versus IRX6-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX6→partner) and Y-score (partner→IRX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KRTAP20-2 →	+0.096	+5.196	<.001	.005	3	1
OVARY	RBMY1A1 →	+0.143	+5.807	<.001	.001	3	1
OVARY	MTRNR2L5 →	+0.035	+5.196	<.001	.005	3	1
LUNG_NSCLC_LUAD	DAOA →	+0.014	+4.681	<.001	.003	3	1
BLOOD_Leukemia	FAM24A →	+0.064	+4.969	<.001	.003	3	1
BLOOD_Leukemia	TSSK1B →	+0.014	+4.874	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 276 associations by consensus.

KRTAP20-2 by IRX6 expression — OVARY

Explore this box plot interactively →