IRX6

Across TCGA cell cohorts, IRX6 mutation is significantly associated with the mutation status of many other genes, with 4,257 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IRX6-associated genes across cancer lineages are CHST12, PRR14L, and GPAA1. Each is linked with IRX6 in more than 4 cancer types. Because this analysis shows association rather than direction, both IRX6-to-partner and partner-to-IRX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHST12 grouped by IRX6-low versus IRX6-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX6→partner) and Y-score (partner→IRX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CHST12 →	+5.000	+5.000	.006	.006	1	5
BLOOD_Leukemia	PRR14L →	+3.338	+4.083	.003	.003	1	4
LARGE_INTESTINE	GPAA1 →	+1.819	+2.029	.005	.005	1	4
LARGE_INTESTINE	UNC13B →	+1.989	+2.148	.003	.003	1	4
BLOOD_Leukemia	PCDHA1 →	+2.975	+4.741	<.001	<.001	1	4
BLOOD_Leukemia	LEMD3 →	+5.560	+4.736	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,257 associations by consensus.

CHST12 by IRX6 expression — KIDNEY

Explore this box plot interactively →