IRX4

Across TCGA patient cohorts, IRX4 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,963 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IRX4-associated GO terms across cancer lineages are Placenta development, Proximal/distal pattern formation, and Purine nucleotide salvage. Each is linked with IRX4 in more than 12 cancer types. Because this analysis shows association rather than direction, both IRX4-to-partner and partner-to-IRX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Placenta development grouped by IRX4-low versus IRX4-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX4→partner) and Y-score (partner→IRX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Placenta development →	+0.053	+0.267	<.001	<.001	2	13
ESCA	Proximal/distal pattern formation →	+0.077	+2.624	<.001	<.001	3	11
ESCA	Purine nucleotide salvage →	+0.052	+1.658	<.001	<.001	3	10
STAD	Mitotic nuclear membrane organization →	+0.076	+0.434	<.001	<.001	3	10
TGCT	Positive regulation of cysteine-type endopeptidase activity →	+0.031	+1.918	<.001	<.001	3	9
STAD	Positive regulation of intrinsic apoptotic signaling pathway →	+0.062	+0.455	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,963 associations by consensus.

Placenta development by IRX4 expression — STAD

Explore this box plot interactively →