IRX4

Across TCGA patient cohorts, IRX4 protein abundance is significantly associated with the RNA expression of many other genes, with 11,423 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible IRX4-associated genes across cancer lineages are BRMS1L, PFDN4, and RASSF2. Each is linked with IRX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRX4-to-partner and partner-to-IRX4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IRX4 versus BRMS1L in BRCA, with a Pearson correlation of -0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX4→partner) and Y-score (partner→IRX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BRMS1L →	-0.738	-1.707	.003	<.001	3	1
BRCA	PFDN4 →	-0.736	-1.114	.004	.005	3	1
BRCA	RASSF2 →	-1.303	-1.123	<.001	.006	3	1
BRCA	SMARCA1 →	-1.893	-1.236	<.001	.001	3	1
BRCA	CYB5B →	-0.564	-1.002	.001	.009	3	1
BRCA	ZDHHC2 →	-1.262	-1.274	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,423 associations by consensus.

IRX4 vs BRMS1L — BRCA

Explore this scatter interactively →