IRX4

Across TCGA patient cohorts, IRX4 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRX4-associated genes across cancer lineages are p90 RSK, ATM, and Caspase-7-cleavedD198. Each is linked with IRX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRX4-to-partner and partner-to-IRX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by IRX4-low versus IRX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX4→partner) and Y-score (partner→IRX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p90 RSK →	+0.159	+1.594	.024	.042	3	2
UCEC	ATM →	-0.504	-2.736	.002	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.954	+2.827	<.001	.001	3	2
UCEC	eIF4E →	+0.185	+1.847	.016	.008	3	1
UCEC	ERK2 →	+0.146	+3.459	.038	.005	3	1
UCEC	JNK2 →	+0.212	+2.125	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

p90 RSK by IRX4 expression — UCEC

Explore this box plot interactively →