IRX4

Across TCGA cell cohorts, IRX4 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible IRX4-associated genes across cancer lineages are PM20D1, GPR33, and PRAMEF7. Each is linked with IRX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRX4-to-partner and partner-to-IRX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PM20D1 grouped by IRX4-low versus IRX4-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX4→partner) and Y-score (partner→IRX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PM20D1 →	+0.071	+2.781	.002	.006	3	2
LARGE_INTESTINE	GPR33 →	+0.105	+3.204	.004	<.001	3	2
URINARY_TRACT	PRAMEF7 →	+0.032	+4.087	<.001	.009	3	1
OESOPHAGUS	RIT2 →	+0.194	+2.857	<.001	.007	3	1
OESOPHAGUS	CCDC185 →	+0.269	+3.321	.004	.007	3	1
UPPER_AERODIGESTIVE_TRACT	OR56A5 →	+0.045	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

PM20D1 by IRX4 expression — OESOPHAGUS

Explore this box plot interactively →