IRX3

Across TCGA patient cohorts, IRX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,164 significant associations in total. THCA shows the largest number of these associations.

The most reproducible IRX3-associated GO terms across cancer lineages are Proximal/distal pattern formation involved in nephron development, Pattern specification involved in kidney development, and Loop of Henle development. Each is linked with IRX3 in more than 29 cancer types. Because this analysis shows association rather than direction, both IRX3-to-partner and partner-to-IRX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Proximal/distal pattern formation involved in nephron development grouped by IRX3-low versus IRX3-high in LAML.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX3→partner) and Y-score (partner→IRX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	Proximal/distal pattern formation involved in nephron development →	+1.525	+3.114	<.001	<.001	3	30
SCLC	Pattern specification involved in kidney development →	+0.858	+1.046	<.001	<.001	3	26
SCLC	Loop of Henle development →	+0.178	+1.103	<.001	<.001	3	22
ESCA	Regulation of cell communication by electrical coupling →	+0.076	+1.708	<.001	<.001	3	18
ESCA	Regulation of cell communication by electrical coupling involved in cardiac conduction →	+0.086	+1.851	<.001	<.001	3	18
SCLC	Segment specification →	+0.161	+1.097	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,164 associations by consensus.

Proximal/distal pattern formation involved in nephron development by IRX3 expression — LAML

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