IRX3

Across TCGA patient cohorts, IRX3 protein abundance is significantly associated with the RNA expression of many other genes, with 2,788 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible IRX3-associated genes across cancer lineages are NCF4, SAMHD1, and IL2RA. Each is linked with IRX3 in more than 2 cancer types. Because this analysis shows association rather than direction, both IRX3-to-partner and partner-to-IRX3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IRX3 versus NCF4 in BRCA, with a Pearson correlation of -0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX3→partner) and Y-score (partner→IRX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NCF4 →	-0.745	-0.870	.001	.001	3	2
BRCA	SAMHD1 →	-0.777	-0.622	.001	.004	3	2
BRCA	IL2RA →	-0.934	-0.803	.003	.002	3	2
BRCA	PRXL2B →	+0.595	+0.456	<.001	.006	3	2
BRCA	SLAMF8 →	-0.913	-0.892	.003	.001	3	2
BRCA	CTSS →	-1.099	-0.951	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,788 associations by consensus.

IRX3 vs NCF4 — BRCA

Explore this scatter interactively →