IRX3

Across TCGA patient cohorts, IRX3 mutation is significantly associated with the RNA expression of many other genes, with 600 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRX3-associated genes across cancer lineages are LINC01707, DPP4-DT, and LINC02210-CRHR1. Each is linked with IRX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRX3-to-partner and partner-to-IRX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01707 grouped by IRX3-low versus IRX3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX3→partner) and Y-score (partner→IRX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LINC01707 →	+0.134	+4.278	<.001	.001	3	2
UCEC	DPP4-DT →	+0.349	+1.950	<.001	.009	3	2
LUAD	LINC02210-CRHR1 →	+0.766	+4.194	<.001	.009	3	2
UCEC	AKR1B10P2 →	+0.029	+2.452	.007	.008	3	2
BLCA	SNORD115-1 →	+0.328	+7.640	<.001	.009	3	1
UCEC	IGLV2-8 →	+2.268	+3.711	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 600 associations by consensus.

LINC01707 by IRX3 expression — COAD

Explore this box plot interactively →