IRX3

Across TCGA cell cohorts, IRX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,605 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible IRX3-associated GO terms across cancer lineages are Specification of loop of Henle identity, Proximal/distal pattern formation involved in nephron development, and Specification of nephron tubule identity. Each is linked with IRX3 in more than 15 cancer types. Because this analysis shows association rather than direction, both IRX3-to-partner and partner-to-IRX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Specification of loop of Henle identity grouped by IRX3-low versus IRX3-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX3→partner) and Y-score (partner→IRX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Specification of loop of Henle identity →	+1.628	+2.732	<.001	<.001	3	16
KIDNEY	Proximal/distal pattern formation involved in nephron development →	+1.735	+2.096	<.001	<.001	3	15
KIDNEY	Specification of nephron tubule identity →	+1.735	+2.096	<.001	<.001	3	15
URINARY_TRACT	Regulation of cell communication by electrical coupling involved in cardiac conduction →	-0.141	-2.030	.003	<.001	3	9
BLOOD_Lymphoma	Regulation of tumor necrosis factor-mediated signaling pathway →	+0.078	+0.944	<.001	.001	3	8
UPPER_AERODIGESTIVE_TRACT	Purine nucleoside triphosphate metabolic process →	+0.084	+1.223	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,605 associations by consensus.

Specification of loop of Henle identity by IRX3 expression — OVARY

Explore this box plot interactively →