IRX3

Across TCGA cell cohorts, IRX3 mutation is significantly associated with the RNA expression of many other genes, with 212 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IRX3-associated genes across cancer lineages are GCAT, NBN, and ARMC1. Each is linked with IRX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRX3-to-partner and partner-to-IRX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCAT grouped by IRX3-low versus IRX3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX3→partner) and Y-score (partner→IRX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GCAT →	+1.134	+3.169	.004	.009	3	1
LARGE_INTESTINE	NBN →	+0.694	+3.082	<.001	.007	3	1
LARGE_INTESTINE	ARMC1 →	+0.482	+3.502	<.001	.001	3	1
LARGE_INTESTINE	ASPN →	+0.034	+2.426	<.001	.005	3	1
LARGE_INTESTINE	MDM1 →	+0.580	+3.169	.002	.009	3	1
LARGE_INTESTINE	SNX3 →	+0.467	+3.237	.006	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 212 associations by consensus.

GCAT by IRX3 expression — LARGE_INTESTINE

Explore this box plot interactively →