IRX2

Across TCGA patient cohorts, IRX2 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,000 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IRX2-associated proteins across cancer lineages are IRX2_S186, IRX2_S317, and PLAC9. Each is linked with IRX2 in more than 5 cancer types. Because this analysis shows association rather than direction, both IRX2-to-partner and partner-to-IRX2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IRX2 versus IRX2_S186 in GBM, with a Pearson correlation of 0.83.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX2→partner) and Y-score (partner→IRX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IRX2_S186 →	+2.851	+2.528	<.001	<.001	3	6
BRCA	IRX2_S317 →	+1.379	+1.523	<.001	<.001	3	4
CCRCC	PLAC9 →	+0.849	+0.504	<.001	.001	3	3
CCRCC	PPP1R12B →	+0.921	+0.569	<.001	<.001	3	3
GBM	VAV3 →	-0.609	-1.061	<.001	.002	3	3
LSCC	SEC24A →	-0.281	-0.862	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,000 associations by consensus.

IRX2 vs IRX2_S186 — GBM

Explore this scatter interactively →