IRX2

Across TCGA patient cohorts, IRX2 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRX2-associated genes across cancer lineages are PCNA, Src_pY527, and INPP4B. Each is linked with IRX2 in more than 2 cancer types. Because this analysis shows association rather than direction, both IRX2-to-partner and partner-to-IRX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by IRX2-low versus IRX2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX2→partner) and Y-score (partner→IRX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.384	+3.178	.001	.010	3	3
UCEC	Src_pY527 →	-0.394	-1.874	.014	.049	3	3
COAD	INPP4B →	-0.371	-3.161	.044	.019	3	2
COAD	JNK_pT183_Y185 →	-0.311	-3.161	.015	.019	3	2
UCEC	Cyclin-B1 →	+0.635	+3.700	.002	.001	3	2
UCEC	EGFR_pY1068 →	-0.223	-1.765	.017	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

PCNA by IRX2 expression — COAD

Explore this box plot interactively →