IRX2

Across TCGA cell cohorts, IRX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,987 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible IRX2-associated GO terms across cancer lineages are Specification of loop of Henle identity, Proximal/distal pattern formation involved in nephron development, and Specification of nephron tubule identity. Each is linked with IRX2 in more than 9 cancer types. Because this analysis shows association rather than direction, both IRX2-to-partner and partner-to-IRX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Specification of loop of Henle identity grouped by IRX2-low versus IRX2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX2→partner) and Y-score (partner→IRX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Specification of loop of Henle identity →	+1.587	+2.585	<.001	<.001	3	10
LUNG_SCLC	Proximal/distal pattern formation involved in nephron development →	+1.735	+3.257	<.001	<.001	3	8
LUNG_SCLC	Specification of nephron tubule identity →	+1.735	+3.257	<.001	<.001	3	8
BREAST	Pattern specification involved in metanephros development →	+1.309	+2.233	<.001	<.001	3	8
OESOPHAGUS	Negative regulation of mRNA metabolic process →	+0.095	+1.833	.001	<.001	3	6
LUNG_SCLC	Regulation of stem cell population maintenance →	+0.054	+2.031	.003	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,987 associations by consensus.

Specification of loop of Henle identity by IRX2 expression — OESOPHAGUS

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