IRX2

Across TCGA cell cohorts, IRX2 mutation is significantly associated with the RNA expression of many other genes, with 127 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IRX2-associated genes across cancer lineages are MTMR3, TNRC6B, and IFT27. Each is linked with IRX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRX2-to-partner and partner-to-IRX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTMR3 grouped by IRX2-low versus IRX2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX2→partner) and Y-score (partner→IRX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MTMR3 →	+0.839	+3.064	<.001	.009	3	2
LARGE_INTESTINE	TNRC6B →	+1.000	+3.064	<.001	.009	3	2
LARGE_INTESTINE	IFT27 →	+1.031	+3.064	<.001	.009	3	2
LARGE_INTESTINE	ARR3 →	+0.127	+3.510	.004	.005	3	2
BLOOD_Leukemia	PLEKHG4B →	+1.962	+3.257	<.001	.009	3	2
BLOOD_Leukemia	ONECUT1 →	+0.691	+3.418	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 127 associations by consensus.

MTMR3 by IRX2 expression — LARGE_INTESTINE

Explore this box plot interactively →