IRX1

Across TCGA patient cohorts, IRX1 mutation is significantly associated with the RNA expression of many other genes, with 3,358 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRX1-associated genes across cancer lineages are ZNF367, GTF2A2, and RNU6-97P. Each is linked with IRX1 in more than 3 cancer types. Because this analysis shows association rather than direction, both IRX1-to-partner and partner-to-IRX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF367 grouped by IRX1-low versus IRX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX1→partner) and Y-score (partner→IRX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF367 →	+0.645	+1.736	<.001	<.001	3	4
UCEC	GTF2A2 →	+0.317	+2.638	.007	<.001	3	4
READ	RNU6-97P →	+0.792	+4.525	<.001	<.001	3	3
READ	PRELID3BP2 →	+0.165	+4.681	<.001	.003	3	3
UCEC	SNHG30 →	+0.334	+1.882	.004	.001	3	3
BLCA	ERHP1 →	+0.402	+3.437	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,358 associations by consensus.

ZNF367 by IRX1 expression — UCEC

Explore this box plot interactively →