IRX1

Across TCGA patient cohorts, IRX1 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRX1-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and FASN. Each is linked with IRX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IRX1-to-partner and partner-to-IRX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by IRX1-low versus IRX1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX1→partner) and Y-score (partner→IRX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.230	+3.717	<.001	<.001	3	3
UCEC	eIF4E →	+0.161	+1.920	.012	.008	3	3
COAD	FASN →	+0.433	+1.915	.002	.009	3	3
UCEC	PCNA →	+0.218	+1.947	<.001	<.001	3	3
COAD	ASNS →	+0.454	+1.915	.001	.009	3	3
UCEC	mTOR_pS2448 →	-0.111	-2.308	.015	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

Caspase-7-cleavedD198 by IRX1 expression — COAD

Explore this box plot interactively →