IRX1

Across TCGA cell cohorts, IRX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,522 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible IRX1-associated GO terms across cancer lineages are Negative regulation of mRNA metabolic process, Stress granule assembly, and Epigenetic regulation of gene expression. Each is linked with IRX1 in more than 5 cancer types. Because this analysis shows association rather than direction, both IRX1-to-partner and partner-to-IRX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mRNA metabolic process grouped by IRX1-low versus IRX1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX1→partner) and Y-score (partner→IRX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of mRNA metabolic process →	+0.051	+1.529	<.001	.001	3	6
SOFT_TISSUE	Stress granule assembly →	+0.068	+1.141	.001	.008	3	6
LUNG_SCLC	Epigenetic regulation of gene expression →	+0.061	+1.689	<.001	.003	3	6
OESOPHAGUS	Establishment of RNA localization →	+0.086	+2.108	.005	<.001	3	6
LUNG_SCLC	Negative regulation of mRNA processing →	+0.062	+1.519	.006	.007	3	6
SOFT_TISSUE	Regulation of cytoplasmic translation →	+0.057	+1.507	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,522 associations by consensus.

Negative regulation of mRNA metabolic process by IRX1 expression — SOFT_TISSUE

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