IRX1

Across TCGA cell cohorts, IRX1 mutation is significantly associated with the RNA expression of many other genes, with 1,342 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IRX1-associated genes across cancer lineages are SGSM3, TBC1D30, and WRAP53. Each is linked with IRX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRX1-to-partner and partner-to-IRX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SGSM3 grouped by IRX1-low versus IRX1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRX1→partner) and Y-score (partner→IRX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SGSM3 →	+0.650	+2.158	.001	.004	3	2
LARGE_INTESTINE	TBC1D30 →	+0.803	+2.158	.003	.004	3	2
LARGE_INTESTINE	WRAP53 →	+0.635	+2.850	<.001	<.001	3	2
LARGE_INTESTINE	LYG1 →	+1.013	+2.850	<.001	<.001	3	2
LARGE_INTESTINE	SGCB →	+1.002	+2.850	<.001	<.001	3	2
LARGE_INTESTINE	STOX1 →	+1.129	+2.850	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,342 associations by consensus.

SGSM3 by IRX1 expression — LARGE_INTESTINE

Explore this box plot interactively →