Across TCGA pan-cancer cohorts, IRS2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IRS2 data layer compared with 24 for mass-spec protein and 10 for mutation status.
The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher IRS2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IRS2 expression acts as an unfavorable survival marker.
PDAC, CCRCC, and LUAD are the cancer types where IRS2 mass-spec protein most reproducibly stratifies survival.
mass-spec protein survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.