Across TCGA patient cohorts, IRS2 RNA expression is significantly associated with the RNA expression of many other genes, with 18,641 significant associations in total. THYM shows the largest number of these associations.

The most reproducible IRS2-associated genes across cancer lineages are ZKSCAN8, ZFHX3, and MNT. Each is linked with IRS2 in more than 29 cancer types. Because this analysis shows association rather than direction, both IRS2-to-partner and partner-to-IRS2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRS2→partner) and Y-score (partner→IRS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	ZKSCAN8 →	+1.046	+0.879	<.001	<.001	3	29
THYM	ZFHX3 →	+1.375	+1.441	<.001	<.001	3	29
CHOL	MNT →	+0.813	+1.923	.001	<.001	2	30
ACC	CALCOCO1 →	+1.121	+1.722	<.001	<.001	3	29
THYM	NORAD →	+1.378	+1.672	<.001	<.001	3	28
UVM	EPC2 →	+0.958	+0.657	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,641 associations by consensus.

Exploration

IRS2 survival (RNA) · tumor vs normal (RNA) · all IRS2 data types