Across TCGA patient cohorts, IRS2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRS2-associated genes across cancer lineages are mTOR_pS2448, PCNA, and PDCD4. Each is linked with IRS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both IRS2-to-partner and partner-to-IRS2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRS2→partner) and Y-score (partner→IRS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.226	-3.700	.001	.001	3	2
UCEC	PCNA →	+0.324	+2.584	.001	.011	3	2
UCEC	PDCD4 →	-0.775	-2.584	<.001	.011	3	2
UCEC	ATM →	-0.827	-3.700	<.001	.001	2	3
UCEC	EGFR_pY1068 →	-0.334	-2.584	.004	.010	3	1
UCEC	eIF4E →	+0.248	+3.013	.011	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

IRS2 survival (RNA) · tumor vs normal (RNA) · all IRS2 data types